ENANTEX – Testosterone Enanthate 300mg

What is Testosterone Enanthate?
Testosterone Enanthate is a synthetic version of the male sex hormone, testosterone. It belongs to the class of androgens and anabolic steroids. This medication is primarily used in hormone replacement therapy (HRT) to treat men with low testosterone levels, a condition known as hypogonadism. It can also be used for other medical conditions, such as hormone therapy in transgender men or treating delayed puberty.

Mechanism of Action

Testosterone Enanthate works by supplementing or replacing testosterone in men whose bodies do not produce enough. Once injected, it is gradually absorbed into the bloodstream from the muscle, where the ester (enanthate) is broken down, releasing testosterone. The testosterone then acts on various tissues to exert its anabolic (muscle-building) and androgenic (masculinizing) effects.

Indications (Uses)
Testosterone Enanthate is prescribed for:

Hypogonadism in Men: Primary (testicular failure) or secondary (pituitary/hypothalamic failure) causes. Delayed Puberty in Males: Stimulates the onset of puberty in boys with delayed sexual development.

Transgender Hormone Therapy: It is part of masculinizing hormone therapy for transgender men. Breast Cancer in Women: It may be used in certain types of breast cancer in postmenopausal women as part of palliative care.

Dosage and Administration
Testosterone Enanthate is administered as an intramuscular injection. The dosage depends on the condition being treated.

For Hypogonadism: 50-400 mg injected every 2-4 weeks.

For Delayed Puberty: A dose tailored to stimulate normal puberty, usually lower than in adults.

Transgender Men: 50-200 mg weekly or 100-200 mg biweekly.

Administration: Injections are usually given in the buttock (gluteal muscle), thigh, or deltoid by a healthcare provider, or self-administered under guidance. The long half-life of the enanthate ester means the drug is slowly absorbed over several days to weeks.

Pharmacokinetics

Onset of Action: Testosterone Enanthate is a long-acting ester, and the effects generally start to become noticeable after several days. Half-Life: The half-life of Testosterone Enanthate is approximately 4-5 days, with effects lasting up to 2-3 weeks after injection. Metabolism and Excretion: It is metabolized primarily in the liver and excreted via urine.

Contraindications
Testosterone Enanthate should not be used in: Men with known or suspected prostate cancer. Men with breast cancer. Individuals with severe heart, liver, or kidney disease. Women who are pregnant or breastfeeding. Individuals allergic to testosterone or any of the ingredients in the formulation.

Side Effects
Like other testosterone therapies, Testosterone Enanthate can cause a range of side effects, from mild to severe.

Common Side Effects: Acne, Oily skin, Increased body or facial hair, Hair loss (male pattern baldness), Injection site reactions (pain, swelling).

Serious Side Effects: Enlarged prostate (benign prostatic hyperplasia) or worsened prostate cancer. Blood clots, deep vein thrombosis (DVT), or pulmonary embolism. Heart attack or stroke, particularly in older men or those with pre-existing conditions. Gynecomastia (breast enlargement in men). Polycythemia (increased red blood cell count), which increases the risk of blood clots. Liver dysfunction or toxicity (in rare cases).

Psychological Side Effects: Mood swings, Aggression, Depression or anxiety, Insomnia.

Virilization in Women: Testosterone Enanthate should not be used by women unless prescribed for a specific medical condition, as it can cause irreversible effects such as deepened voice, facial hair growth, and clitoral enlargement.

Warnings and Precautions

Cardiovascular Risks: Testosterone therapy has been linked to increased risks of cardiovascular events, such as heart attack and stroke, especially in older men or those with pre-existing heart conditions.

Prostate Health: Testosterone can stimulate the growth of prostate cancer cells, so regular prostate screening is recommended during therapy.

Liver Toxicity: While less common, long-term use of injectable testosterone can cause liver dysfunction.

Fluid Retention: Testosterone can cause water retention, which may exacerbate conditions like heart failure or hypertension.

Sleep Apnea: Testosterone therapy can worsen sleep apnea in individuals who already have this condition.

Drug Interactions
Testosterone Enanthate may interact with: Anticoagulants: Increases the risk of bleeding when used with blood thinners like warfarin. Diabetes Medications: It can lower blood glucose levels, potentially affecting insulin or other diabetes medications. Corticosteroids: May increase fluid retention when used with corticosteroids. Cyclosporine: May increase the risk of toxicity due to elevated cyclosporine levels.

Always inform your healthcare provider of all medications, supplements, or herbal products you are taking.

Overdose
Symptoms of overdose include severe nausea, vomiting, swelling of limbs due to fluid retention, and prolonged or painful erections. In case of suspected overdose, seek medical help immediately.

Monitoring
Patients on Testosterone Enanthate therapy should undergo regular monitoring, which includes: Testosterone Levels: To ensure the dosage is appropriate. Prostate Health: Regular screening for prostate cancer and prostate-specific antigen (PSA) testing, particularly in older men. Liver Function: Liver function tests to monitor for potential toxicity.

Red Blood Cell Count: Monitoring for polycythemia, which can increase the risk of blood clots.

Storage
Store Testosterone Enanthate at room temperature, away from light and moisture. Keep it out of reach of children.
Do not freeze the medication.

Special Populations
Children and Adolescents: Use of testosterone in adolescents should be closely monitored to avoid early closure of the growth plates, which could stunt growth.

Elderly Men: Older men are at a higher risk for side effects, particularly cardiovascular and prostate-related issues.

Women: Not recommended unless used for specific conditions like breast cancer, as it can cause virilizing effects.

Conclusion
Testosterone Enanthate is a widely used form of testosterone replacement therapy that offers long-lasting effects due to its slow-release formula. While effective in treating testosterone deficiency and other conditions, it carries significant risks, particularly in older men or those with cardiovascular or prostate health concerns. It requires careful monitoring by a healthcare provider to avoid complications.